Professor
Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine Sichuan University
Address:Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine Sichuan University, Sichuan Province, Chengdu, 610041, P. R. China
Phone:86-13032896118
E-mail:zhou108@163.com
Dr. Zhou main research interests lie in the study of understanding the molecular mechanism of cancer and cancer drugs. The focus of Dr. Zhou’s research program is to define the role of microRNA-451a in colorectal cancer and breast cancer. The ongoing research project including 1) MiR-451a introduced ER-stress associated apoptosis in colorectal cancer. 2) microRNA-451a is associated with ERα expression and response to tamoxifen in breast cancer. Dr. Zhou still interesting in looking for useful content of Chinese medicine. Dr. Zhou has published 61 refereed papers including 35 SCI papers and 12 book chapters. With her expertise, Dr. Zhou served as an evaluation expert for China CFDA. Now she is the director of the department of pharmacology at Sichuan University.
Education and Training
West China University of Medical Sciences MD, Medicine 1985-1994; Pharmacology, 2006
Harvard University, Boston, USA, Visiting Scholar, 1998
The Scripps Research Institute, San Diego, USA , Visiting Scholar, 2000
Area of Interest
Molecular mechanism of colorectal cancer and breast cancer, anticancer drug of Chinese medicine, Cell signal
Selected Publication
1. Jian Chen, Litao Liu, Ruanling Hou, Zhenjun Shao, Yiying Wu, Xiajing Chen Liming Zhou*, Calycosin promotes proliferation of estrogen receptor-positive cells via estrogen receptors and ERK1/2 activation in vitro and in vivo,Cancer Letters. 2011, 308(2): 144–151
2. Jianlei Zhaog, Jian Chen, Wenfu Tang, Lihong Wan, Wenbi Xiong and Liming Zhou*, Efect of Da-Cheng-Qi decoction on pancreatitis-associated lung injury in patients and anti-infammatory responses in rat models,Pharmaceutical Biology, 2011, 49(10):1058–1064.
3. Shao Zhen-Jun, Zheng Xiao-Wei, Feng Ting, Huang Juan, Chen Jian, Wu Yi-Ying, Li-Ming Zhou*, Tu Wen-Wei, Li Hong. Andrographolide exerted its antimicrobial effects by up-regulation of humanβ-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells.Can J Physiol Pharmacol 2012; 84(4):507-512
4. Wu YY, Wan LH, Zheng XW, Shao ZJ, Chen J, Liu LT, Kuang WJ, Tan XS, Li-Ming Zhou*. Inhibitory effects of β,β-Dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo.Phytother Res 2012; 26(5):764-767
5. Li-Hong Wan, Jian Chen, Liang Li, Wen-Bi Xiong, and Li-Ming Zhou*, Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats,Pharmaceutical Biology, 2011; 49(11): 1204–1209
6. Yuan-Yuan Zhang, Jin-Nan Li, Harry Hua-Xiang Xia, Shi-Lun Zhang, Jiang Zhong, Yi-Ying Wu , Shi-Kun Miao , Li-Ming Zhou*, Protective effects of losartan in mice with chronic viral myocarditis induced by coxsackie virus B3.Life Sciences, 2013; 10(92):1186–1194
7. Yao Xiong, Xiu Ying Ma, Ziran Zhang, Zhen Jun Shao, Yuan Yuan Zhang and Li-Ming Zhou*, Apoptosis induced byβ,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in human breast carcinoma MCF-7 cells.Oncology Letters 2013;6(6):1789-1793
8. Li-Tao Liu, Li Hong Wan, Xiao Hong Song, Yao Xiong, Shao Ju Jin , Li-Ming Zhou*, Relevance of class 1 integrons and extended spectrum β-lactamases in drug resistant Escherichia coli.Molecular Medicine Reports, 2013;8(4):1251-1255, acetylation in hepatocellular carcinoma cells.European Journal of Pharmacology, 2013,69: 8137–144
9. Xiuying Ma, Shaoju Jin, Yuanyuan Zhang, Lihong Wan, Yanyan Zhao, Li-Ming Zhou* Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo.Phytother Res. 2014;28(4): 560–567
10 Shaoju Jin, Yishuang Mu, Xiaodong Wang, Zhenru Liu, Lihong Wan, Yao Xiong, Yuanyuan Zhang, Li Li, Li-Ming Zhou*, Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma.Moleculor Biology Reports. 2014; 41(5):3393-3399.
11. Yao Xiong, Yuan-Yuan Zhang, Yi-YingWu, Xiao-Dong Wang, Li-Hong Wan, Li- Li , Li-Ming Zhou*, Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages,Life Sciences, 2014;106(1-2):19-24
12．Wen-Bi Xiong, Zhen-Jun Shao†, Yao Xiong, Jian Chen, Yun Sun, Ling Zhu and Li-Ming Zhou* Dehydroandrographolide enhances innate immunity of intestinal tract through up-regulation the expression of hBD-2,DARU Journal of Pharmaceutical Sciences, 2015;23(1):1-7
13. Zhenru Liu, Baodong Ling, Li-Ming Zhou*, Prevalence of 16S rRNA methylase, modifying enzyme, and extended-spectrum beta-lactamase genes among Acinetobacter baumannii isolates
14. Zhen-Ru Liu , Yi Song, Li-Hong Wan, Yuan-Yuan Zhang , Li-Ming Zhou*, Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3ζ, estrogen receptor α, and autophagy,Life Sciences2016;149(15):104-113
15 Yun Zeng, Liqin Wang, Zijian Zhou, Xiaoyong Wang, Yang Zhang, Junqing Wang,c Peng Mi, Gang Liu and Li-Ming Zhou*, Gadolinium hybrid iron oxide nanocomposites for dual T1- and T2-weighted MR imaging of cell labeling.Biomaterials Science, 2017; 5(1), 50-56
16 Ke Xu, Yuan-Yuan Zhang, Bin Han, Yang Bai, Yao Xiong,Yi Song and Li-Ming Zhou*, Suppression subtractive hybridization identified differentially expressed genesin colorectal cancer: microRNA-451a as a novel colorectal cancer related gene,Tumor Biology;2017:1-9.
17 Yiying Wu, Yi Song, Yao Xiong, Xiaodong Wang, Ke Xu, Bin Han Yang Bai, Li Li, Yuanyuan Zhang, Li-Ming Zhou*, MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer，Cell Physiol Biochem.2017;43(3):945-958