Dr. Canhua HUANG

 

 

Current Position:

·Dean of West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University (2017-)

·Professor and Principal Investigator of State Key Laboratory of Biotherapy, West China Hospital, Sichuan University (2005-)

Honors and awards:

·Director, Innovative Research Group of the National Nature Science Foundation of China (2019-)

·Chief Scientist for National 973 Program (2013-2017)

·National Science Fund for Distinguished Young Scholars of China (2012)

Service:

·Committee member, the Proteomics Division of the Chinese Society of Biochemistry and Molecular Biology

·Committee member, the Metabolism Division of the Chinese Society of Biochemistry and Molecular Biology

·Committee member, the Chinese Union of Translational Medicine

·Committee member, the Tumor Metastasis Division of the Chinese Anticancer Association

Editorial Boards:

·Editorial Board,Signal Transduct Target Ther

·Associate Editor-in-Chief,MedComm

·Editorial Board,Proteomics

Research interests:

·Regulation of Redox signals and tumorigenesis

·Molecular mechanism of viral carcinogenesis

Representative publications:

1. Huang Z, Zhou J-K, Wang K, Chen H-N, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C*, Wei X*, Peng Y*. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma.Hepatology. 2019; doi: 10.1002/hep.30930.

2. Jiang J, Zhang L, Chen H-N, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K*, Huang C*. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.Autophagy. 2020; 16(1):106-122.

3. Zhang Z, Gao W, Zhou L, Chen Y, Qin S, Zhang L, Liu J, He Y, Lei Y, Chen H-N, Han J, Zhou Z-G, Nice EC, Li C, Huang C*, Wei X*. Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy.Theranostics. 2019; 9(17):4878-4892.

4. Chen H-N, Chen Y, Zhou Z-G, Wei YQ, Huang C*. A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery.Autophagy. 2019; 15(4):733-734.

5. Zhou L, Gao W, Wang K, Huang Z, Zhang L, Zhang Z, Zhou J, Nice EC, Huang C*. Brefeldin A Inhibits Colorectal Cancer Growth by Triggering Bip/Akt-regulated Autophagy.FASEB J. 2019;33(4):5520-5534.

6. Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C*. Targeting Metabolic-redox Circuits for Cancer Therapy.Trends Biochem Sci. 2019; 44(5):401-414.

7. Zhang Z, Zhang L, Zhou L, Lei Y, Zhang Y*, Huang C*. Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress.Redox Biol. 2019; 25:101047.

8. Chen Y, Chen H-N, Wang K, Zhang L, Huang Z, Liu JY, Zhang Z, Luo MC, Lei YL, Peng Y, Zhou Z-G, Wei YQ, Huang C*. Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.J Hepatol. 2019;70(1):66-77.

9. Liu Y, Guo JZ, Liu Y, Wang K, Ding W, Wang H, Liu X, Zhou S, Lu XC, Yang HB, Xu C, Gao W, Zhou L, Wang YP, Hu W, Wei Y, Huang C*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce α-Hydroxybutyrate for HPV-induced Cervical Tumor Growth.Nat Commun. 2018;9(1):4429.

10. Lan J, Huang Z, Han J, Shao J*, Huang C*. Redox regulation of microRNAs in cancer.Cancer Lett. 2018; 418:250-259.

11. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M*, Huang C*, Wei Y. Identification of Annexin A2 as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux.Autophagy. 2018; 14(2):269-282.

12. Wang K, Gao W, Dou Q, Chen H, Li Q, Nice EC, Huang C*. Ivermectin Induces PAK1-mediated Cytostatic Autophagy in Breast Cancer.Autophagy. 2016;12(12)2498-2499.

13. Dou Q, Chen H, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y and Huang C*. Ivermectin induces cytostatic autophagy by blocking PAK1/Akt axis in breast cancer.Cancer Res. 2016; 76(15):4457-69.

14. Li X, He S, Li R, Zhou X, Zhang S, Yu M, YeY, Wang Y, Huang C*, Wu M*. Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-ediated immune activation and infiltration.Nat Microbiol. 2016;1(10):16132.

15. Xie N, Yuan K, Zhou L, Wang K, Chen H, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC, Wei Y, Zhang H*, Yang J* and Huang C*. PRKAA1/AMPK restricts HBV replication through promotion of autophagic degradation.Autophagy. 2016; 12(9):1507-20.

16. Huang Z, Zhou L, Chen Z, Nice EC, Huang C*. Stress Management by Autophagy: Implications for Chemoresistance.Int J Cancer. 2016; 139(1):23-32.

17. Chen HN, Yuan K, Xie N, Wang K, Huang Z, Chen Y, Dou Q, Wu M, Nice EC, Zhou ZG*, Huang C*. PDLIM1 stabilizes the E-cadherin/Beta-catenin complex to prevent epithelial-mesenchymal transition and metastatic potential of colorectal cancer cells.Cancer Res. 2016; 76(5):1122-34.

18. Yuan K, Lei Y, Chen H, Chen Y, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W, Wu Min, Xiang R, Feitelson MA, Nice EC, Wei Y, Huang C*. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.Cell Death Differ. 2016; 23(4):616-27.

19. Li X, He S, Zhou X, Ye Y, Tan S, Zhang S, Li R, Yu M, Jundt MC, Hidebrand A, Wang Y, Li G*, Huang C*, Wu M*. Lyn delivers bacteria to lysosomes for eradication through TLR2-initiated autophagy related phagocytosis.PLoS Pathog. 2016; 12(1):e1005363.

20. Zhang L, Wang K, Lei Y, Li Q, Nice EC, Huang C*. Redox Signaling: Potential Arbitrator of Autophagy and Apoptosis in Therapeutic Response.Free Radical Bio Med. 2015; 89:452-465.

21. Lei Y, Wang K, Deng L, Chen Y, Nice EC, Huang C*. Redox Regulation of Inflammation: Old Elements, a New Story.Med Res Rev. 2015; 35(2):306-40.

22. Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K, Lei Y, Yuan K, Li Y, Lan J, Cheng L, Xie N, Xiang R, Nice EC, Huang C*, Wei Y. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking.Autophagy. 2014; 10(7):1241-55.

23. Liu R, Li J, Xie K, Zhang T, Lei Y, Chen Y, Zhang L, Huang K, Wang K, Wu H, Wu M, Nice EC, Huang C*, Wei Y. FGFR4 promotes stroma-induced epithelial to mesenchymal transition in colorectal cancer.Cancer Res. 2013; 73(19):5926-35. (2013, Oct 1st, Cover story；Highlighted as breaking advance in Cancer Res, 2013, Oct 15th )

24. Wen X, Wu J, Wang F, Liu B*, Huang C*, Wei Y. Deconvoluting the role of reactive oxygen species and autophagy in human diseases.Free Radic Biol Med. 2013; 65:402-410.

25. Liu R, Huang L, Li J, Zhou X, Zhang H, Zhang T, Lei Y, Wang K, Xie N, Zheng Y, Wang F, Nice EC, Rong L, Huang C*, Wei Y. HIV Infection in Gastric Epithelial Cells.J Infect Dis. 2013; 208(8):1221-30.

26. Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C*, Wei Y. GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.Carcinogenesis. 2013; 34(12):2861-9.

27. Yuan K, Xie K, Fox J, Zeng H, Gao H, Huang C*, Wu M*. Decreased Levels of miR-224 and the Passenger Strand of miR-221 Increase MBD2, Suppressing Maspin and Promoting Tumor Growth and Metastasis in Mice.Gastroenterology. 2013; 145(4):853-64.e9.

28. Deng L, Lei Y, Liu R, Li J, Yuan K, Li Y, Chen Y, Liu Y, Lu Y, Edwards CK 3rd, Huang C*, Wei Y. Pyrvinium targets autophagy addiction to promote cancer cell death.Cell Death Dis. 2013; 4:e614.

29. Wang K, Zhang T, Dong Q, Nice EC, Huang C*, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.Cell Death Dis. 2013; 4:e537

30. Zhou S, Liu R, Yuan K, Yi T, Zhao X, Huang C*, Wei Y. Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis.Mass Spectrom Rev. 2013; 32(4):267-311.

31. Zhou S, Yi T, Liu R, Bian C, Qi X, He X, Wang K, Li J, Zhao X*, Huang C*, Wei Y. Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis.Mol Cell Proteomics. 2012; 11(7):M112.017988.

32. Lei Y, Huang K, Gao C, Lau QC, Pan H, Xie K, Li J, Liu R, Zhang T, Xie N, Shan Nai H, Wu H, Zhao X, Dong Q, Nice E, Huang C*, Wei Y. Proteomics identification of ITGB3 as a key regulator in ROS-induced migration and invasion of colorectal cancer cells.Mol Cell Proteomics. 2011; 10(10):M110.005397.

33. Yuan K, Huang C*, Fox J, Gaid M, Weaver A, Li GP, Singh BB, Gao H, Wu M*. Elevated inflammatory response in Caveolin-1 deficient mice with P. aeruginosa infection is mediated by STAT3 and NF-{kappa}B.J Biol Chem. 2011; 286(24):21814-25.

34. Zhou S, Li Y, Huang F, Zhang B, Yi T, Li Z, Luo H, He X, Zhong Q, Bian C, Lin X, Qi X, Liu P, Huang C, Zhao X*, Wei Y. Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation.Cancer Lett. 2012 May 1;318(1):14-25.

35. Wang K, Liu R, Li J, Mao J, Xie N, Wu J, Lei Y, Zhang T, Zeng J, Wu H, Chen L, Huang C.* Wei Y. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling.Autophagy. 2011; 7(9):966-78.

36. Li J, Liu R, Lei Y, Wang K, Lau Q.C, Xie N, Zhou S, Nie C, Chen L, Wei Y, and Huang C*. Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010; 6(6) :711-24.

37. Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Zeng D, Tong A, Chen L, Wei Y, Huang C*. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma.Mol Cancer. 2010; 9:81

38. Liu R, Li Z, Bai S, Zhang H, Tang M, Lei Y, Chen L, Liang S, Zhao Y, Wei Y, Huang C*. Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone mediated gastric carcinogenic signaling pathway.Mol Cell Proteomics. 2009; 8(1):70-85.

39. Li Z, Zhao X*, Bai S, Wang Z, Chen L, Wei Y, Huang C*. Proteomic identification of cyclophilin A as a potential prognostic factor and therapeutic target in endometrial carcinoma.Mol Cell Proteomics. 2008; 7(10):1810-23.

40. Wang Z, Jiang L, Huang C*, Li Z, Tong A, Chen L, Shen J, Gao F, Chen Q*. Comparative proteomic approach to screening of potential diagnostic and therapeutic targets for Oral Squamous Cell Carcinoma.Mol Cell Proteomics. 2008; 7(9):1639-50.

41. Li Z, Huang C*, Bai S, Pan X, Zhou R, Wei Y, and Zhao X*. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach.Int J Cancer. 2008; 123:2377-83.